Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability
Identifieur interne : 001463 ( Main/Corpus ); précédent : 001462; suivant : 001464Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability
Auteurs : M. Melzacka ; F. Block ; W. Weseman ; G. Sturm ; -H. SontagSource :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1989-09-01.
Abstract
Summary: The structure-activity relationship of two isomeric 1-aminoadamantanes, 1-C-ethylaminoadamantane (D 174) and 1-amino-3-ethyladamantane (D 175), on membrane anisotropy and the excitability of neurons was studied in the CNS of the rat and in the decerebrated cat. Mass spectrometric analysis showed that after a single, 40 mg/kg dose, D 174 and D 175 were unevenly distributed within the CNS of the rat, moreover the distribution pattern of the two substances was different. As measured by fluorescence depolarization in controls the membrane anisotropy was found to be higher in the older parts as compared with the younger parts of the CNS. After i.p. application of 40 mg/kg the membrane anisotropy was reduced in the cortex by D 174, whereas D 174 and D 175 increased the rigidity in striatal membranes. If cortical membranes were incubated with the substances, the fluidizing effect of D 174 was more prominent than that of D 175. In the decerebrated cat only D 174 in a dose of 5 mg/kg i.p. raised the discharge of spinal alpha-motoneurones significantly. The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.
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DOI: 10.1007/BF02248665
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability</title><author><name sortKey="Melzacka, M" sort="Melzacka, M" uniqKey="Melzacka M" first="M." last="Melzacka">M. Melzacka</name><affiliation><mods:affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Block, F" sort="Block, F" uniqKey="Block F" first="F." last="Block">F. Block</name><affiliation><mods:affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</mods:affiliation></affiliation></author><author><name sortKey="Weseman, W" sort="Weseman, W" uniqKey="Weseman W" first="W." last="Weseman">W. Weseman</name><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Sturm, G" sort="Sturm, G" uniqKey="Sturm G" first="G." last="Sturm">G. Sturm</name><affiliation><mods:affiliation>Department of Endocrinology, Clinic of Obstetrics and Gynecology, Philipps-University, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Sontag, H" sort="Sontag, H" uniqKey="Sontag " first="-H." last="Sontag">-H. Sontag</name><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:82C7C048655DA0720EF085CB377E746AB74EFCA3</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1007/BF02248665</idno><idno type="url">https://api.istex.fr/document/82C7C048655DA0720EF085CB377E746AB74EFCA3/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001463</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability</title><author><name sortKey="Melzacka, M" sort="Melzacka, M" uniqKey="Melzacka M" first="M." last="Melzacka">M. Melzacka</name><affiliation><mods:affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Block, F" sort="Block, F" uniqKey="Block F" first="F." last="Block">F. Block</name><affiliation><mods:affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</mods:affiliation></affiliation></author><author><name sortKey="Weseman, W" sort="Weseman, W" uniqKey="Weseman W" first="W." last="Weseman">W. Weseman</name><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Sturm, G" sort="Sturm, G" uniqKey="Sturm G" first="G." last="Sturm">G. Sturm</name><affiliation><mods:affiliation>Department of Endocrinology, Clinic of Obstetrics and Gynecology, Philipps-University, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Sontag, H" sort="Sontag, H" uniqKey="Sontag " first="-H." last="Sontag">-H. Sontag</name><affiliation><mods:affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title><title level="j" type="abbrev">J Neural Transm Gen Sect</title><idno type="ISSN">0936-3076</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1989-09-01">1989-09-01</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="153">153</biblScope><biblScope unit="page" to="164">164</biblScope></imprint><idno type="ISSN">0936-3076</idno></series><idno type="istex">82C7C048655DA0720EF085CB377E746AB74EFCA3</idno><idno type="DOI">10.1007/BF02248665</idno><idno type="ArticleID">Art2</idno><idno type="ArticleID">BF02248665</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0936-3076</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The structure-activity relationship of two isomeric 1-aminoadamantanes, 1-C-ethylaminoadamantane (D 174) and 1-amino-3-ethyladamantane (D 175), on membrane anisotropy and the excitability of neurons was studied in the CNS of the rat and in the decerebrated cat. Mass spectrometric analysis showed that after a single, 40 mg/kg dose, D 174 and D 175 were unevenly distributed within the CNS of the rat, moreover the distribution pattern of the two substances was different. As measured by fluorescence depolarization in controls the membrane anisotropy was found to be higher in the older parts as compared with the younger parts of the CNS. After i.p. application of 40 mg/kg the membrane anisotropy was reduced in the cortex by D 174, whereas D 174 and D 175 increased the rigidity in striatal membranes. If cortical membranes were incubated with the substances, the fluidizing effect of D 174 was more prominent than that of D 175. In the decerebrated cat only D 174 in a dose of 5 mg/kg i.p. raised the discharge of spinal alpha-motoneurones significantly. The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>M. Melzacka</name><affiliations><json:string>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</json:string><json:string>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</json:string></affiliations></json:item><json:item><name>F. Block</name><affiliations><json:string>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</json:string></affiliations></json:item><json:item><name>Prof. Dr. W. 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The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.</abstract><qualityIndicators><score>7.109</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 774 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1287</abstractCharCount><pdfWordCount>4613</pdfWordCount><pdfCharCount>25894</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>208</abstractWordCount></qualityIndicators><title>Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability</title><genre><json:string>research-article</json:string></genre><host><volume>1</volume><pages><last>164</last><first>153</first></pages><issn><json:string>0936-3076</json:string></issn><issue>3</issue><subject><json:item><value>Pharmacology/Toxicology</value></json:item><json:item><value>Psychiatry</value></json:item><json:item><value>Neurology</value></json:item></subject><journalId><json:string>722</json:string></journalId><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1435-1463</json:string></eissn><title>Journal of Neural Transmission - 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Mass spectrometric analysis showed that after a single, 40 mg/kg dose, D 174 and D 175 were unevenly distributed within the CNS of the rat, moreover the distribution pattern of the two substances was different. As measured by fluorescence depolarization in controls the membrane anisotropy was found to be higher in the older parts as compared with the younger parts of the CNS. After i.p. application of 40 mg/kg the membrane anisotropy was reduced in the cortex by D 174, whereas D 174 and D 175 increased the rigidity in striatal membranes. If cortical membranes were incubated with the substances, the fluidizing effect of D 174 was more prominent than that of D 175. In the decerebrated cat only D 174 in a dose of 5 mg/kg i.p. raised the discharge of spinal alpha-motoneurones significantly. The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pharmacology/Toxicology</term></item><item><term>Psychiatry</term></item><item><term>Neurology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1988-08-16">Created</change><change when="1989-09-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-2">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/82C7C048655DA0720EF085CB377E746AB74EFCA3/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Vienna</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>722</JournalID><JournalPrintISSN>0936-3076</JournalPrintISSN><JournalElectronicISSN>1435-1463</JournalElectronicISSN><JournalTitle>Journal of Neural Transmission - 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Mass spectrometric analysis showed that after a single, 40 mg/kg dose, D 174 and D 175 were unevenly distributed within the CNS of the rat, moreover the distribution pattern of the two substances was different. As measured by fluorescence depolarization in controls the membrane anisotropy was found to be higher in the older parts as compared with the younger parts of the CNS. After i.p. application of 40 mg/kg the membrane anisotropy was reduced in the cortex by D 174, whereas D 174 and D 175 increased the rigidity in striatal membranes. If cortical membranes were incubated with the substances, the fluidizing effect of D 174 was more prominent than that of D 175. In the decerebrated cat only D 174 in a dose of 5 mg/kg i.p. raised the discharge of spinal alpha-motoneurones significantly. The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Aminoadamantanes</Keyword><Keyword>pharmacokinetics</Keyword><Keyword>CNS</Keyword><Keyword>membrane anisotropy</Keyword><Keyword>excitability</Keyword><Keyword>spinal alpha- and gamma-motoneurons</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Melzacka</namePart><affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</affiliation><affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Block</namePart><affiliation>Department of Pharmacology, Max-Planck-Institute of Experimental Medicine, Göttingen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof. Dr.</namePart><namePart type="given">W.</namePart><namePart type="family">Weseman</namePart><affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Sturm</namePart><affiliation>Department of Endocrinology, Clinic of Obstetrics and Gynecology, Philipps-University, Marburg, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="given">-H.</namePart><namePart type="family">Sontag</namePart><affiliation>Department of Neurochemistry, Institute of Physiological Chemistry, Philipps-University, Hans-Meerwein-Strasse, D-3550, Marburg, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1988-08-16</dateCreated><dateIssued encoding="w3cdtf">1989-09-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: The structure-activity relationship of two isomeric 1-aminoadamantanes, 1-C-ethylaminoadamantane (D 174) and 1-amino-3-ethyladamantane (D 175), on membrane anisotropy and the excitability of neurons was studied in the CNS of the rat and in the decerebrated cat. Mass spectrometric analysis showed that after a single, 40 mg/kg dose, D 174 and D 175 were unevenly distributed within the CNS of the rat, moreover the distribution pattern of the two substances was different. As measured by fluorescence depolarization in controls the membrane anisotropy was found to be higher in the older parts as compared with the younger parts of the CNS. After i.p. application of 40 mg/kg the membrane anisotropy was reduced in the cortex by D 174, whereas D 174 and D 175 increased the rigidity in striatal membranes. If cortical membranes were incubated with the substances, the fluidizing effect of D 174 was more prominent than that of D 175. In the decerebrated cat only D 174 in a dose of 5 mg/kg i.p. raised the discharge of spinal alpha-motoneurones significantly. The results suggest that the membrane architecture is more affected by D 174 as compared with D 175 which is reflected by a greater effect on membrane anisotropy as well as on the activity of spinal alpha-motoneurones.</abstract><relatedItem type="host"><titleInfo><title>Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title></titleInfo><titleInfo type="abbreviated"><title>J Neural Transm Gen Sect</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1989-09-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Neurology</topic></subject><identifier type="ISSN">0936-3076</identifier><identifier type="eISSN">1435-1463</identifier><identifier type="JournalID">722</identifier><identifier type="IssueArticleCount">9</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1989</date><detail type="volume"><number>1</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>153</start><end>164</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin></recordInfo></relatedItem><identifier type="istex">82C7C048655DA0720EF085CB377E746AB74EFCA3</identifier><identifier type="DOI">10.1007/BF02248665</identifier><identifier type="ArticleID">Art2</identifier><identifier type="ArticleID">BF02248665</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1989</recordOrigin></recordInfo></mods></metadata><enrichments><istex:refBibTEI 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